trinity rna seq workshop

; Luc Girard, PhD; Esra Akbay, PhD, Antibody;Checkpoint blockade;Immune monitoring;Immune suppression;NK/NKT cell;Solid tumors;T cell;Tumor antigens;Tumor evasion, The novel telomerase-directed telomere-targeted anticancer agent 6-thio-dG (THIO) demonstrates potent activity and induces antitumor immunity in hepatocellular carcinoma (HCC) models. Purevdorj B. Olkhanud, M.D., Ph.D.; Refika B. Turnier; Kimberly Dunham; Masaki Terabe, PhD; Seth Steinberg, PhD; Brenda Roberson; Lauren V. Wood, MD; David F. Stroncek, MD; Ira H. Pastan; Jay A. Berzofsky, MD, PhD; Hoyoung M. Maeng, MD, Clinical trial;Dendritic cell;T cell;Tumor antigens;Vaccine, CTX130 allogeneic CRISPR-Cas9-engineered chimeric antigen receptor (CAR) T cells in patients with advanced clear cell renal cell carcinoma: Results from the Phase 1 COBALT-RCC study, Sumanta Pal, MD; Ben Tran, MD; John B.A. How do you transform your passion for science into equitable outreach? Octavia Bane, PhD; Enamul Bhuiyan, PhD; Paul Kennedy, PhD; Muhammed Shareef, MD; Pauline Hamon, PhD; Mark Buckup, PhD; Sacha Gnjatic, PhD; Stefanie Hectors, PhD; Hung Kam Cheung; Elizabeth Miller; Maria Isabel Fiel, MD; Stephen Ward; Myron E. Schwartz, MD; Thomas U. Marron, MD, PhD; Miriam Merad, MD, PhD; Bachir Taouli, MD, MSHA, Biomarkers;Checkpoint blockade;Immune adjuvant;Solid tumors;T cell, PRELIMINARY RESULTS OF A PILOT STUDY OF INTRATUMORAL INJECTION OF AUTOLOGOUS DENDRITIC CELLS AFTER HIGH-DOSE CONFORMAL EXTERNAL BEAM RADIOTHERAPY IN UNRESECTABLE PRIMARY LIVER CANCERS. Monika Sponheimer; Gerulf Hnel; Lisa Rohrbacher; Nora Philipp; Daniel Nixdorf; Anetta Marcinek; Christian Wichmann, Dr. Microglial MorphOMICs unravel region- and sex-dependent morphological phenotypes from postnatal development to degeneration. STING signaling compensates for mutation burden-low tumors to stimulate the immune response. van der Veldt; Ellen Kapiteijn; Karijn Suijkerbuijk; Kalijn Bol; Geke A.P. is that they suggest stable states or phenotypes of microglia associated with a disease context, such as neurodegeneration. Gonye; Keren Yizhak; Moshe Sade-Feldman; David Liu; Ryan J. Sullivan; Keith T. Flaherty, Biomarkers;Checkpoint blockade;Cytokine;Immune monitoring;Immune suppression;Monocyte/Macrophage;Myeloid cells;Proteomics;Solid tumors;Tumor microenvironment, Using Additional Morphology Markers in NanoString GeoMx Whole Transcriptome Atlas assay to assess NSCLC tumor subtype, Jessica Runyon, MA; Christian Nievera, PhD; Vijay Baichwal, PhD, Bioinformatics;Biomarkers;Gene expression;RNA;Solid tumors;Tumor microenvironment, The immune expression landscape of solid tumors with tertiary lymphoid structures, Maria-Fernanda Senosain, PhD; R.J. J. Seager, Jr., Ph.D.; Erik Van Roey; Shuang Gao; Mary K. Nesline; Jeffrey Conroy, BS; Sarabjot Pabla, PhD, Bioinformatics;Solid tumors;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment, Clinical implication of Exhaustive T-Cell Environment in Uveal Melanoma Patients. MATCHER: An algorithm for integrating single cell transcriptomic and epigenomic data using manifold alignment. Ph.D.; Farzonai Muzaffar; Ryan Campbell; Abenezer Abera, Adoptive immunotherapy;Antigen presenting cells;Cytokine;Neoantigens;RNA;Solid tumors;T cell;T cell lineages;Tumor antigens;Tumor microenvironment, Discovery, cloning and functional validation of a neoantigen specific patient derived TCR on the Berkeley Lights platform, with implications in personalized cancer immunotherapy. ; Kylynda C. Bauer, Ph.D.; Yuta Myojin, MD, PhD; Mohamed-Reda Benmebarek, Ph.D.; Layla Greten; Justin McCallen, M.D. Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner. The Chemical Biology Interest Group aims to better promote crosstalk between the two fields. A. Sierra is a recipient of a research grant from Hoffmann La Roche. Willumsen, PhD; David McDermott, MD; Toni K. Choueiri, MD, Biomarkers;Checkpoint blockade;Clinical trial;Solid tumors. How similar are peripherally derived macrophages and microglia? Efficient ex-vivo expansion of adaptive NKG2C+/CD57+ NK cells from CMV-positive donors using dendritic cells derived from the acute myeloid cell line DCOne. Distinct amyloid-beta and tau-associated microglia profiles in Alzheimer's disease. A phase I study of intralymphatic (IL) administration of ipilimumab (IPI) with intravenous nivolumab (NIVO) using the Sofusa DoseConnect™ device in patients with advanced melanoma. medschool.duke.edu Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin. Amani Djouadi; Niksa Roki, Ph.D.; Carlos Castro, Ph.D. Antigen presenting cells;Immune adjuvant;T cell;TLR;Tumor antigens;Vaccine, EFFICACY STUDY OF STC-1010 ANTITUMOR VACCINE ASSOCIATED WITH STANDARD CHEMOTHERAPIES ON MC 38 SYNGENEIC COLON CANCER TUMOR MODEL, Corinne Tortorelli, Pharm.D, Ph.D; Celine Gongora; Doriane Mathe; Benoit Pinteur; Lionel Chalus; Paul Bravetti; Nicolas Gadot; Sylvie Lantuejoul; Charles Dumontet; Franois Ghiringhelli, Biomarkers;Dendritic cell;Immune monitoring;Monocyte/Macrophage;Neoantigens;Solid tumors;Tumor antigens;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment;Vaccine, Listeria-based immunotherapy sculpts CD8+ T cell response in the tumor microenvironment to control renal cell carcinoma, Mariam Oladejo, B.Pharm; Laurence M. Wood, PhD, T cell;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment, Therapeutic vaccines consisting of cancer germline antigen-based synthetic long peptides are immunogenic in human hepatocellular carcinoma patients, Yannick S. Rakk, MD, MSc; Marij J. Schoenmaekers-Welters, PhD; Lisanne Noordam, MD, MSc; Sanne Boekestijn; Luc Magre, BSc; Robbie J. Luijten, BSc; Rachelle S. van Gemerden, MSc; Monique T.A. From the Cajal alumni Achucarro and Rio-Hortega to the rediscovery of never-resting microglia. The goal of this interest group session is to build a community of researchers in the field of membrane proteins. ; Terence J. Purdon, M.S. Haas BJ, et al. Chiu; Jong-Seok Lee; James Chih-Hsin Yang; Edward B. Garon; Giovanna Finocchiaro; Myung-Ju Ahn; Alexander Luft; Gregory A. Landers; Andrea Basso; Hua Ma; Julie Kobie; John Palcza; Razvan Cristescu; Lawrence Fong; Alexandra Snyder; Jianda Yuan; Martin Gutierrez, MD, A phase 1, open-label, dose escalation and expansion study of CUE-102 monotherapy in HLA-A*0201 positive patients with WT1-positive recurrent/metastatic cancers, Steven P. Margossian, MD, PhD; John D. Powderly, II, MD; Nashat Y. Gabrail, MD; Yvonne M. Saenger, MD; J. Eva Selfridge; Nataliya Uboha; Jun Gong; Brian A. Tmem119-EGFP and Tmem119-CreERT2 Transgenic Mice for Labeling and Manipulating Microglia. Neoadjuvant in situ intratumoral vaccination with empty cowpea mosaic virus nanoparticles is effective against canine mammary cancer. TREM2 expression in the human brain: a marker of monocyte recruitment?. Neuroinflammation is inflammation of neural tissue particularly mediated by glial cells. ; Rachel Salazar, PhD, Bispecifics;Costimulation;Cytokine;NK/NKT cell;Solid tumors;T cell;Targeted therapy;Tumor antigens, CD64-directed scFv fusion protein exhibits cytotoxicity and is a tool for site-specific diagnosis of acute myeloid leukemia, Siew Tai, PhD; Sikozile S. Ncembu, Mr; Stefan Barth, PhD, DMSc; Sue Harrison, PhD, Antibody;Biomarkers;Leukemia/Lymphoma;Myeloid cells;Targeted therapy;Tumor antigens, Distinct anti-tumor response to Listeria-based vaccines between orthotopic and subcutaneous syngeneic mouse models of renal cell carcinoma, Hong-My Nguyen, B.Pharm; Laurence M. Wood, PhD, Immune suppression;MDSC;T cell;Tumor antigens;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment;Vaccine, Identification of Vasoactive Intestinal Peptide (VIP)-specific Single-Chain Antibody Fragments (scFvs) via Yeast Surface Display, Khue G. Nguyen, PhD; David A. Zaharoff, PhD, Antibody;Biomarkers;Immune suppression;Regulatory T cell (Treg cell);T cell;Targeted therapy, XmAb143, an engineered IL18 heterodimeric Fc-fusion, features improved stability, reduced potency, and insensitivity to IL18BP, Alex Nisthal, PhD; Sung-Hyung Lee, PhD; Christine Bonzon, PhD; Ruschelle Love, MS; Kendra N. Avery, PhD; Rumana Rashid, PhD; Panida Lertkiatmongkol, PhD; Nicole Rodriguez, PhD; Sher Karki, PhD; Norman J. Barlow, PhD, DVM, MBA; Seung Chu, PhD; Gregory L. Moore, PhD; John R. Desjarlais, PhD, Cytokine;Inflammation;NK/NKT cell;T cell;Tumor infiltrating lymphocytes (TILs), STC-15, an oral small molecule inhibitor of the RNA methyltransferase METTL3, inhibits tumour growth through activation of anti-cancer immune responses and synergises with immune checkpoint blockade, Yaara Ofir -Rosenfeld; Oliver Rausch, PhD; Jerry McMahon; Lina Vasiliauskaite; Claire Saunders; Alexandra Sapetschnig; Georgia Tsagkogeorga; Mark Albertella; Marie Carkill; Jezrom Self-Fordham; Josefin-Beate Holz, Checkpoint blockade;Gene expression;RNA;Solid tumors;T cell;Targeted therapy;Tumor infiltrating lymphocytes (TILs), Characterization and validation of a humanized lead antibody against OX003, a novel immuno-oncology target, Chander S. Peddaboina, PhD; Arnima Bisht, PhD; Murray Cox, BS; Antonn Cheeseman, BS; Christian Rohlff; Abderrahim Fandi, MD, PhD, Adoptive immunotherapy;Antibody;Biomarkers;Costimulation;Solid tumors;T cell;Tumor antigens;Tumor evasion;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment, A hormone-based bispecific T cell engager (BiTE)-like molecule for the treatment of neuroendocrine tumors, Eleonora Pelle, MD; Mauro Cives; Elliot Medina; Charlotte C. Mason; Sebastian Snedal; Xiomar E. Bustos Perez; Leticia Tordesillas, PhD; Miguel Gomez Fontela, PhD; Renata A.M. Rossetti; Gabriele Maiorano; Vincent C. Luca, PhD; Patrick Hwu; Daniel Abate-Daga, PhD; Jonathan R. Strosberg, MD, Bispecifics;Solid tumors;T cell;Tumor microenvironment, Novel, brain penetrant small molecule inhibitor of PD-L1 for targeting glioblastoma and brain metastasis, Dhanalakshmi Sivanandhan, PhD; Sridharan Rajagopal, PhD; Chandru Gajendran, M.Sc; Naveen Sadhu M, M.Sc; Mohammed Zainuddin, PhD; Ramachandraiah Gosu, PhD; Luca Rastelli, PhD, Checkpoint blockade;Immune suppression;Regulatory T cell (Treg cell);Solid tumors;T cell;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment. No matter where you are in your career, having great interview skills can help you make the next step. This training can be taken by all life sciences. Ramos, PhD; Sandra Delebecq; Adele Ponzoni; Lisa Guzzi, Biomarkers;Solid tumors;Tumor microenvironment;Tumor stroma, AB598, a therapeutic anti-human CD39 antibody, binds and inhibits CD39 enzymatic activity in vivo to promote anti-tumor immunity, Kaustubh Parashar; Julie Clor; Amy E. Anderson, PhD; Urvi Vani; Jaskirat Singh; Enzo Stagnaro; Ferdie Soriano, BS; Angelo Kaplan; Janine Kline; Lisa Seitz, MS; Stephen W. Young; Nigel P. Walker, PhD; Matthew Walters; Ester Fernandez-Salas; Christine Bowman, PhD, Antibody;Antigen presenting cells;Chemotherapy;Cytokine;Dendritic cell;Monocyte/Macrophage;Myeloid cells;Solid tumors;Tumor microenvironment, Intratumoral S100A8-to-CD8 ratio in inflamed Merkel cell carcinoma tumors correlates with response to PD-1 pathway blockade, Shira Tabachnick-Cherny, PhD; Thomas Pulliam; Haroldo J. Rodriguez Chevez, BS; Kimberly S. Smythe, BS; Rima Kulikauskas; Kristina Lachance; Daniel Hippe; Paul T. Nghiem, MD, PhD, Biomarkers;Immune suppression;MDSC;Monocyte/Macrophage;Myeloid cells;Solid tumors;T cell;Tumor microenvironment, InteractPrint predicts clinically meaningful interactions between cancer epithelial cells and immune cells: Lessons from a single-cell breast cancer atlas, Lily Xu, B.A. The workshop will bring together laboratories using cryo-EM, X-ray crystallography, biochemistry, nuclear microinjection, genetics, cell biology, CRISPR/Cas9-AID gene editing, live imaging, viral and animal models to elucidate interactions between nucleoporins, mRNA and RNA-accessory proteins at the nuclear pore complex. Local Cues Establish and Maintain Region-Specific Phenotypes of Basal Ganglia Microglia. Go; Armen Mardiros; David G. Maloney, MD, PhD; Lu-Min Wong; Alexander Kamb, PhD; Han Xu, PhD; Julian R. Molina, MD, PhD, TCR-like chimeric-antigen-receptor to recognize neoepitopes derived from driver mutations, CAR T cells;Neoantigens;Solid tumors;T cell, Dysfunctional immune synapses restrain anti-DIPG activity of CAR T cells, Jorge Ibanez, PhD; Haley Houke; Michaela Meehl; Jennifer Ocasio; Nikhil Hebbar; Paulina Velasquez; Suzanne Baker; Giedre Krenciute, PhD, Adoptive immunotherapy;CAR T cells;Immune suppression;Pediatric tumors;Solid tumors;T cell, Increased potency and functional persistence in vitro of a next-generation NY-ESO-1-specific TCR therapy incorporating Gen-R, Helle Jensen; Rachel Fukuda; Megan Murt; Xiao Wang; Lora Zhao; Sheila Lou; Purnima Sundar; Christopher Navas; Andrew Jimena; Amanda Sims; Travis Beckett; Shobha Potluri; Rowena Martinez; David Chian; Candace Sims; Quinn Walker; Abira Bandyopadhyay; Breanna Pamintuan; Bijan Boldajipour; Chang-Chih Wu; Martin Wohlfahrt; Byoung Ryu; Viola C. Lam; Rachel C. Lynn; Hajime Hiraragi; Johannes Breuning; Ashley Hamilton; Fotini Kouri; Jack Euesden; Sara Brett; Blythe Sather, Adoptive immunotherapy;Solid tumors;T cell;Targeted therapy, A real-world case of second chimeric antigen receptor t-cell therapy, Jacinth Joseph, MD; Dennis Marjoncu, PharmD; Kori Holman, PharmD; Sara Leidy, PharmD, Adoptive immunotherapy;CAR T cells;Leukemia/Lymphoma, Bead-bound antibody-activation of T cells provides sub-optimal metabolic programming and tumour control compared to dendritic cell-activated T cells, Meghan Kates, BSc; Gavin Yuen; Michael St. Paul, PhD; Alisha R. Elford; Pamela S. Ohashi, PhD; Sam Saibil, MD, PhD, Adoptive immunotherapy;Dendritic cell;Metabolism;T cell, CRISPR-mediated insertion of IL-12 into the PDCD1 locus improves the antitumor activity of TCR-T cells against solid tumors, Segi Kim; Choi Park; Sunhwa Lee; Hyeongryeol Choi; Chan Hyuk Kim, Adoptive immunotherapy;Cytokine;Solid tumors;T cell, Expansion of tumor-infiltrating lymphocytes from head and neck squamous cell carcinoma to assess the successful expansion factors for developing adoptive cell therapy, Mofazzal Hossain, MBBS; Jong Hyeok Kim; Hyun Lee, MD; Chae-Lyul Lim; Gyungyub Gong; Hee Jin Lee, Adoptive immunotherapy;T cell;Tumor infiltrating lymphocytes (TILs), Neoantigen-specific expansion of tumor-infiltrating lymphocytes enables effective treatment of p53-mutant cancer in mice, Peter Kim, PhD; Noam Levin; Nolan Vale; Steven A. Rosenberg, MD, PhD, Adoptive immunotherapy;Antigen presenting cells;Neoantigens;Solid tumors;Targeted therapy;Tumor antigens;Tumor infiltrating lymphocytes (TILs), Exogenous GOT2 in CAR-T cells improves metabolic function and preserves early memory T cell subsets, John W. Hinds, PhD; Sujatha Muralidharan, PhD; Ann M. Ranger, PhD; Jennifer A. Coccia; Thomas P. Giordano, III; Emily G. Kuiper, PhD; Pratirodh Koirala, PhD, CAR T cells;Metabolism;Solid tumors;T cell lineages;Tumor infiltrating lymphocytes (TILs), Engineering of potency-enhanced TCR-edited T cells for shared neoantigen-targeted cancer immunotherapy, Lianne Kok; Sander R. Eshuis, MSc; Paula Kroon, PhD; Vanessa Tubb, PhD; Xiangjun Kong, PhD; Carsten Linnemann; Gavin M. Bendle; Jeroen W.J. A novel triple action and pre-clinical safety profile of SLC-3010 predict its favorable translation in the phase I clinical study. The use and limitations of single-cell mass cytometry for studying human microglia function. ; Ian F. Pollack, M.D. How many different microglial states can be identified? Franklin Ning; Thomas Meyer, PhD; Brittney Harrington, PhD; Christina M. Annunziata, MD, PhD, Chemokine;Clinical trial;Cytokine;Monocyte/Macrophage;Myeloid cells;Solid tumors;T cell;Tumor microenvironment, An unbiased survey of tumor reactivity and transcriptional landscape of 1,000 clones of PD-1hi T-cells from peripheral blood during ICB treatment reveals breath and dynamics of anti-tumor immunity, Danielle R. Cook, PhD; Immaculada Creus; Andrea Garcia-Garijo; Pierre Levy; Seon Kinrot; Rodrigo Toledo; Elena Garralda, MD, MSc; Ely Porter, PhD; Xi Chen; Alena Gros, PhD, Adoptive immunotherapy;Checkpoint blockade;Gene expression;Solid tumors;Systems biology;T cell;Targeted therapy;Tumor antigens;Tumor infiltrating lymphocytes (TILs), Mitochondrial transcription is required for the enhanced anti-tumor activity of adoptively transferred stem-like memory T cells. Silvia Guglietta, PhD; Lukas M. Weber, PhD; Bruno Fosso, PhD; Marinella Marzano; Gary Hardiman; Monica M.M. ; Matthias Bruhns, M.Sc. About Our Coalition. ; Bryan Cruz, B.S. Click the buttons to view by topic. Microglia-specific localisation of a novel calcium binding protein, Iba1. ; Gary Kohanbash, Ph.D. Adoptive immunotherapy;Pediatric tumors;Solid tumors;T cell;Tumor antigens;Tumor infiltrating lymphocytes (TILs), anti-TnMuc1 CAR-T Cells that are Conditionally Armed with IL12 Eliminate Adenocarcinomas in Preclinical Models, Albert Gacerez, PhD; Eytan Herzig, PhD; Tiger G. Ren, MD,PhD; Nicole Grant; Jay Danao; Daniel Roche, PhD; Daeun Nam, PhD; Krista McNally; Ben Wang; Melissa Fardy, PhD; Gus Zeiner, PhD, CAR T cells;Cytokine;Gene expression;Immune toxicity;Metabolism;Post-translational modifications;RNA;Solid tumors;T cell;Tumor microenvironment, Generation of cell therapies for diverse applications using microfluidic Cell Squeeze manufacturing technology, Jonathan Gilbert, PhD; Maisam Dadgar; Scott M. Loughhead, PhD; Ipsita Roymoulik; Devin Bridgen, PhD; Howard Bernstein, MD, PhD; Armon Sharei, PhD, Antigen presenting cells;CAR T cells;Solid tumors;T cell;Tumor infiltrating lymphocytes (TILs);Vaccine, Killer cell immunoglobulin-like receptor 2DL2 (KIR2DL2) immune checkpoint as a modulator of T-cell effector function, Miguel Gomez Fontela, PhD; Sebastian Snedal; Daniel Abate-Daga, PhD, CAR T cells;Checkpoint blockade;Cytokine;Immune suppression;Solid tumors;Systems biology;T cell;Targeted therapy, hunTR™: a hyperplex platform for the discovery of neoantigen-reactive T-cell receptors, Guowei Gu, Ph.D Pharm.D; Julissa Simmons; Kristen Rimaila; Gaby Garland; Ugochi Ibekwe; Donghyun Joo; An Lu; Amanda Montoya; Pretty R. Mathew; Hao Zhao; Beatriz A. Santillan; Matthew R. Collinson-Pautz; Drew C. Deniger, Adoptive immunotherapy;Antigen presenting cells;Bioinformatics;Gene expression;Neoantigens;Solid tumors;T cell;T cell lineages;Tumor antigens;Tumor infiltrating lymphocytes (TILs), Multi-Arming and Regulator Dial gene circuits tackle key challenges in solid tumors, Marcela Guzman Ayala, PhD; Michelle Hung, PhD; Deepika Kaveri, PhD; Rebecca Cottman, PhD; Elizabeth Leitner; Priscilla Wong; Ronni Ponek; Enping Hong, PhD; Manan Shah; Andrew Banicki; Lawrence Naitmazi; Kelly Lee, PhD; Wesley Gorman; Russell Gordley, PhD; Philip Lee, PhD; Timothy K. Lu, PhD, Immune suppression;NK/NKT cell;Solid tumors;Targeted therapy, A2B530, an autologous CEA-directed Tmod T-cell therapy with an inhibitory receptor gated by HLA-A*02 to target colorectal, pancreatic, and lung cancer, J. Randolph Hecht, MD; Mark L. Sandberg, PhD; Xueyin Wang; Aaron D. Martin, M.A. Homeostatic has more acceptance, although it is recognized that it is based on a very particular gene signature not shared by microglia across all physiological contexts, such as embryonic and postnatal development, and that several homeostatic states likely exist. - Go and Pathway enrichment Analysis (PantherDB) ; Ryan A. Beasley, Ph.D.; Arpan A. Patel, M.D. A community-based transcriptomics classification and nomenclature of neocortical cell types. Diwakar Davar, MD; Arivarasan Karunamurthy, MD; Joe-Marc J.M. To address these issues, we assembled a group of multidisciplinary experts to discuss our current understanding of microglial states as a dynamic concept and the importance of addressing microglial function. Stephen C. Frederico, M.S. Chemotherapy;Solid tumors;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment, Novel AI-derived approach to identify Lomitapide as an anticancer agent inducing autophagic cell death in colorectal cancer, Bioinformatics;Checkpoint blockade;Chemotherapy;Coinhibition;T cell;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment, Multiple combinational strategies of immunotherapy for urothelial carcinoma in one institution, Jo-Pai Chen, MD; Sung-Hsin Kuo, MD PhD; Wei-Chen Lu, Selective depletion of tumor-specific regulatory T cells in combination with low dose chemotherapy with or without PD-1 blockade improves anti-tumor T cell responses in solid tumors, Dorothe Saddier Axe; Michelle R. Kuhne, PhD; Renu Jain, PhD; Brian M. Weist, PhD, Antibody;Checkpoint blockade;Chemokine;Chemotherapy;Immune suppression;Immune tolerance;Regulatory T cell (Treg cell);T cell;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment, Blocking 'don't-eat-me' signal of CD47-SIRP by anti-SIRPα antibody enhances anti-tumor efficacy of trastuzumab deruxtecan, Mayumi Sue, PhD; Takuya Tsubaki, PhD; Yoko Ishimoto; Shinko Hayashi; Saori Ishida; Yoshitaka Isumi, PhD; Jun Ishiguro, PhD; Reimi Kawaida; Toshiaki Ohtsuka; Teiji Wada, PhD; Toshinori Agatsuma, PhD; Norihito Kawasaki, PhD, Antibody;Antigen presenting cells;Checkpoint blockade;Chemotherapy;Immune suppression;Monocyte/Macrophage;Myeloid cells;Solid tumors;T cell;Targeted therapy, Anti-CLDN18.2 antibody ZL-1211 enhances anti-tumor activities in combination with chemotherapy in gastric cancer models, Anthony Cao, PhD; Qiuping Ye, PhD; Karl Hsu, MD; Hua Gong; Jiaqing Yi, PhD; Haiying Zhou, PhD; Xinyan Tang, PhD, Antibody;Chemotherapy;NK/NKT cell;Solid tumors;Tumor antigens, Novel Renal Cell Carcinoma Immunotherapy Combining TLR9-Targeted STAT3 Antisense Oligonucleotide with PD-1 blockade, Marice Alcantara, PhD; Alexander Chehrazi-Raffle, MD; Nazli Dizman, MD; Wilson Tang, BS; Luis Meza, MD; Zeynep Zengin, MD; Dongfang Wang, PhD; Dayson Moreira, PhD; Alan Horsager, PhD; JoAnn Hsu, BS; Sumanta Pal, MD; Marcin Kortylewski, PhD, Checkpoint blockade;Immune suppression;MDSC;Monocyte/Macrophage;Myeloid cells;TLR;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment, PD1 and LAG3 synergize on CD8+ T cells to hinder IFNγ-dependent anti-tumor immunity, Lawrence P. Andrews, PhD; Carly Cardello; Jian Cui, PhD; Creg Workman, PhD; Dario A. Vignali, PhD, Checkpoint blockade;T cell;Tumor infiltrating lymphocytes (TILs), Development of BCMA-targeted immunotherapy using vaccine-induced antigen-specific memory CD8+ T cells for treating patients with multiple myeloma, Jooeun Bae; Derin Keskin, Ph.D.; Yueyi Huang, M.S. Comparative analysis of CreER transgenic mice for the study of brain macrophages: A case study. How would each person change the format/content using examples to illustrate these changes? Altogether we will prepare a customized course based on the needs and interests of your team. You signed in with another tab or window. Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways. Brian Thompson; David M. Woods, PhD; Ann M. Strange; Carol M. Amato, MS; Jonathan Hester-McCullough; Jeffrey S. Weber, MD, PhD; Amod A. Sarnaik, MD, FACS, Adoptive immunotherapy;Biomarkers;Solid tumors;T cell;T cell lineages;Tumor infiltrating lymphocytes (TILs), Systemic distribution of gamma-delta PSCA-CAR T cells in combination with zoledronate in a model of bone metastatic prostate cancer, Leticia Tordesillas, PhD; Junior Cianne; Jeremy S. Frieling, PhD; Xiomar E. Bustos, MS; Conor C. Lynch, PhD; Daniel Abate-Daga, PhD, Novel, boosted, fully human ROR1-targeting CAR T cells effectively eliminate hematologic and solid tumors, and resist tumor microenvironment, Tri M. Tran; Bal Krishna Chand Thakuri; Saule Nurmukhambetova; Brittany Steimle; Ngoc Tran; Darong Wu, MS; Peirong Hu, PhD; Pradyot Dash; Dina Schneider, PhD, CAR T cells;Cytokine;Solid tumors;T cell;Targeted therapy;Tumor microenvironment, Targeting cold tumors using iPSC-derived CAR T Cells directed to the immune checkpoint molecule and tumor-associated antigen B7-H3, Jon Tuncel; Bahram Valamehr, PhD; Xu Yuan, PhD; Francisco Martinez, PhD; Nicholas Brookhouser; Philip Chu; Duygu Ozmadenci; Zachary Davis; Robert Blum; Bryan Hancock; Bjoern Gaertner; Nicholas Zorko; Shohreh Sikaroodi, PhD; Miguel Meza; Thomas Dailey, BS; Martin Felices; Frank Cichocki; Lauren Fong, PhD; Tom T. Lee, PhD; Raedun Clarke, PhD; John Goulding; Ryan Bjordahl, PhD; Jeffrey S. Miller, MD, CAR T cells;Checkpoint blockade;Solid tumors;T cell;Targeted therapy;Tumor microenvironment, Clinical expansion and persistence of CAR T-cells: An essential biomarker in need of standardization, David Turicek; Victoria Giordani; Naomi Taylor, M.D., Ph.D.; Nirali N. Shah, MD, A novel iPSC-derived CAR-invariant natural killer T (iNKT) cell therapy platform for hematologic malignancies and solid tumors, Akane Urakami, PhD; Tomokuni Shigeura; Makoto Kondo; Mari Isomi; Yuko Kokubu, PhD; Ken-Ichi Suzuki, PhD; Haruhiko Koseki, MD, PhD, Adoptive immunotherapy;CAR T cells;NK/NKT cell;Targeted therapy;Tumor microenvironment, CAR T cells as a surgical adjuvant for unresectable adenocarcinoma, Ugur Uslu, MD; Tong Da; Charles-Antoine Assenmacher; John Scholler; Regina M. Young; Julia Tchou; Carl June, Adoptive immunotherapy;CAR T cells;Solid tumors;Surgery;T cell, Discovery and development of t cell receptors for adoptive t cell therapy against solid tumors, Juliana Velez Lujan, PhD; Hannah Fields; Kan Xing Wu; Natalie Epstein; Florence Chioh; Nicholas Tan; Daniel Carbajo; Neeraja Kulkarni; Lorenz Gerber; Yovita Purwanti; Alessandra Nardin, DVM; Michael Fehlings; Katja Fink; Dan Macleod, Adoptive immunotherapy;Neoantigens;Solid tumors;T cell;Targeted therapy;Tumor antigens, The effects of negative isolation and aggregate strainers on expanded gamma/delta T cells and their cancer cell cytotoxicity, Georg von Massow, MSc, BSc; Kenth Gustafsson; Jack Firth; Steve Oh; Alan Lam, Preclinical studies of TAC01-CLDN18.2, an autologous Claudin 18.2-directed TAC T cell therapy, in the treatment of gastric cancer, Ling Wang, MD; Stacey X. Xu, PhD; Tania Benatar, PhD; Suzanna L. Prosser, PhD; Laura M. Shaver; Ritu R. Randhawa, MSc; Philbert Ip, PhD; Prabha Lal, PhD; Thanyashanthi Nitya-Nootan, BSc; Heather L. MacGregor, PhD; Sadhak Sengupta, PhD; Christopher W. Helsen, PhD; Andreas G. Bader, PhD, Affinity Fine-Tuning Anti-CAIX CAR-T Cells Mitigate On-Target Off-Tumor Side Effects, Yufei Wang, PhD; Alicia Buck; Michael Lynch; Gabriella Kastrunes; Jae-Won Cho; Marion Grimaud; David A. Braun; Cecile Razimbaud; Matthew Chang, MS; Atef Fayed; Audrey Apollon; Ze-Hua Li; Luann Zerefa; Brandon Piel; Elena Ivanova; Dennis Bonal; Kristen L. Jones, LATg; Quang-De Nguyen; Zhu Zhu; Kevin Wei; Rebecca Jennings; Miriam Ficial; Maura Aliezah Sticco-Ivins; Sabina Signoretti, MD; Catherine J. Wu, MD; Toni K. Choueiri, MD; Jon Wee; Cloud P. Paweletz, Ph.D.; Martin Hemberg; Aedin Culhane; David A. Barbie, MD; Gordon J. Freeman, PhD; Wayne Marasco, MD, PhD, Adoptive immunotherapy;CAR T cells;Solid tumors, Targeting B-cell malignancies with anti-ROR1 CAR T-cell therapy, Jinsheng Weng, MD, PhD; Owhofasa O. Agbedia; Jingjing Cao; Xiaoyun Cheng; Shao Qing Kuang; Fuliang Chu; Sridevi Patchv; Yongfu Tang; Divyam Bansal; Jingwei Liu; Neeraj Saini; Sattva S. Neelapu, MD, Adoptive immunotherapy;Antibody;Biomarkers;CAR T cells;Leukemia/Lymphoma;Solid tumors;T cell;Targeted therapy, Manufacture of KSQ-001, a CRISPR/Cas9-engineered TIL (eTIL) therapy, for the treatment of Head and Neck Squamous Cell Carcinoma, Karrie K. Wong, PhD; Leila J. Williams, MS; Nick Constant; Mitali Ghose, MS; Sharon Lin; Frank Thompson; Conor Calnan; Fiona Sharp, PhD; Sean Donnelly; Charles Quinn; Glenn J. Hanna, MD; Frank Stegmeier, PhD; Micah J. Benson, PhD, Oncometabolites in the tumor microenvironment drive altered natural killer cell functional capacity. Breij, PhD, Antibody;Biomarkers;Bispecifics;Cytokine;Solid tumors;T cell;Targeted therapy;Tumor antigens, Selective Small Molecule Inhibitor of Integrin . Vishal Kothari, Ph.D.; Colin Magowan, B.A. Human iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain. By keeping a broad range of topics, we hope to provide novel collaborative opportunities. Voyager V1 (VV1) oncolytic virus combined with immune checkpoint therapy boosts CTL responses to multiple tumor antigens and correspondingly deepens tumor responses in murine models of melanoma, lung and colon cancer. Comparison of the cytokine and chemokine secretome of benign and malignant peritoneal fluid identifies FGF and IL-1R alpha as potential drivers of tumor growth. Attendees will learn about integration of environmental cues with intracellular regulatory pathways to drive immune cell responsiveness. ; Sally Weng; Ellen Duong, PhD; Sarah Blatt, Checkpoint blockade;Solid tumors;T cell;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment;Tumor stroma. All in all, the main message we wish to convey is that inflammation associated with the CNS follows unique rules that need to be fully discerned experimentally and not simply extrapolated from observations in non-nervous tissue. Share new findings and best practices and engage in activities and discussions that forge lasting and fruitful connections. Rachael E. Maynard, MD, PhD Candidate; Allison Fitzgerald; Apsra Nasir; Eric Glasgow, PhD; Sandra Jablonski, PhD; Pieter Van Der Veken; Gray Pearson, PhD; Emily Mace, PhD; Louis M. Weiner, MD, Prognostic value of Natural Killer cell activity and derived neutrophils-to-lymphocytes ratio in non-small cell lung cancer patients receiving immune checkpoint inhibitors, Line Nederby, MSc, PhD; Sara W.C. Wen, MD; Torben S. Hansen, MD; Christa H. Nyhus, MD; Lisbeth Bertelsen, MD; Rikke F. Andersen, MSc, PhD; Anders Jakobsen, MD, DMSc, Professor; Torben F. Hansen, MD, DMSc, Associate Professor, Biomarkers;Checkpoint blockade;Immune suppression;NK/NKT cell;Solid tumors, Complement C3 deficiency increases the anti-tumor immunity of NK cells and controls tumor growth, Girdhari Lal, PhD; PRADIPTA PAL, M.Sc (Integrated Biotechnology); Sourav Paul; Heikrujam Thoihen Meitei; Praneet Wahi; Arvind Sahu, PhD, Cytokine;NK/NKT cell;T cell;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment, Natural Killer cells in immunotherapy-induced MHC-I tumor escape, Eric Miao; Jennifer Poursine-Laurent; Kathleen CF. Combination therapy with anti-VSIG4 and anti-PD-L1 suppress growth of tumor via conditioning of tumor microenvironment. ; Hannah M. Knochelmann, MD, PhD; Amalia M. Rivera-Reyes; Aubrey S. Smith, Ph.D.; Megan M. Wyatt, MS; Guillermo O. Rangel RIvera, B.S. A lymphocyte-microglia-astrocyte axis in chronic active multiple sclerosis. Fluorescence is less bright than in CX3CR1-GFP mice, and generally sufficient for two-photon. In scRNA-seq studies, describe the transcriptional signatures (sets or modules of expressed genes) that can be compared with other studies. Homozygous Mutations in CSF1R Cause a Pediatric-Onset Leukoencephalopathy and Can Result in Congenital Absence of Microglia. Bioinformatics;Biomarkers;Checkpoint blockade;Gene expression;RNA;Solid tumors, Probabilistic mixture models improve calibration of panel-derived tumor mutational burden in the context of both tumor-normal and tumor-only sequencing. ; Roman Kischel, PhD; Veit Bcklein, Dr. Melero, MD, PhD, Adoptive immunotherapy;CAR T cells;Cytokine;Metabolism;RNA;Solid tumors;T cell;Tumor infiltrating lymphocytes (TILs), Harnessing CD39 for the treatment of colorectal cancer and liver metastases by engineered T cells, Alessia Potenza, PhD; Chiara Bonini, MD; Chiara Balestrieri; Luca Albarello; Federica Pedica; Martina Spiga; Francesco Manfredi; Beatrice C. Cianciotti; Claudia De Lalla; Lorena Stasi; Elena Tassi; Silvia Bonfiglio; Giulia M. Scotti; Miriam Redegalli; Donatella Biancolini; Danilo Abbati; Fabio Simeoni; Dejan Lazarevic; Ugo Elmore; Guido Fiorentini; Giulia Di Lullo; Giulia Casorati; Paolo Dellabona; Claudio Doglioni; Giovanni Tonon; Riccardo Rosati; Luca Aldrighetti; Eliana Ruggiero, PhD, Checkpoint blockade;Solid tumors;T cell;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment, Mitochondrial apoptosis mediates CAR T cell cytotoxicity, Alexandra L. Pourzia, MD, PhD; Michael L. Olson, PhD; Stefanie R. Bailey, PhD; Aditi Aryal, BS; Jeremy Ryan, MS; Marcela V. Maus, MD, PhD; Anthony Letai, PhD MD, CAR T cells;Leukemia/Lymphoma;Solid tumors;T cell;Tumor evasion, Developing placental CD34+-derived natural killer cells with high affinity and cleavage resistant CD16 (CYNK-101) in combination with Avelumab for enhanced therapy against PD-L1+ solid tumors, Irene Raitman, PhD; Gavin Foley; Eric He; Hemlata Rana, MS; Niranjan Ghimire, PhD; Xuan Guo, PhD; Robert Hariri, MD PhD; Lin Kang, PhD, Antibody;Checkpoint blockade;Solid tumors;Tumor antigens. Field, PhD; Joshua Messinger; Nathaniel Rice; Matthew Lanahan; Alex Kato; Michael Pokrass, PhD; Heba Nowyhed, Evaluation of the anti-tumor activity of ICVB-1042, a novel E2F-tumor selective oncolytic virus, selectively targeting tumor cells in an established human glioblastoma mouse model, Michael Lyman, PhD; Jessica J. https://doi.org/10.1186/s13059-018-1406-4, Removal of Batch Effects using Distribution-Matching Residual Networks, https://www.nature.com/articles/s41598-017-13665-w, A comparison of single-cell trajectory inference methods: towards more accurate and robust tools, A descriptive marker gene approach to single-cell pseudotime inference, Characterization of cell fate probabilities in single-cell data with Palantir, Inferring population dynamics from single-cell RNA-sequencing time series data, Supervised Classification Enables Rapid Annotation of Cell Atlases, Harmonization and Annotation of Single-cell Transcriptomics data with Deep Generative Models, Cell type classification and discovery across diseases, technologies and tissues reveals conserved gene signatures and enables standardized single-cell readouts, Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage. Mark Landers, B.S. For instance, could engrafted parenchymal macrophages functionally replace the resident microglia despite having a different molecular identity, and could they serve as therapeutic vectors? Preclinical Characterization of D3L-001, a novel bispecific antibody that enhance phagocytosis and eradication of HER2 positive solid tumor via HER2 and CD47 dual blockade. Antigen presenting cells;Costimulation;Cytokine;Dendritic cell;Solid tumors;TLR;Tumor microenvironment, Calcium phosphate biomaterials enhance immunotherapeutic mRNA delivery in melanoma, Hannah L. Martin, BS; Joshua A. Choe, MS; Iris Baurceanu; William L. Murphy, PhD, Cytokine;Gene expression;RNA;Solid tumors;T cell, New viral-delivery of glycan-modifying sialidase induces anti-tumor immunity, Natalia Rodrigues Mantuano, PhD; Michael Sandholzer, MSc. Effects of dibutyltin exposures on translation regulatory factors eIF4E, eIF4B and S6 in human immune cells, Dietary cholesterol-induced gut microbes drive nonalcoholic fatty liver disease pathogenesis in a murine model, Alterations in microbiota-gut-brain axis and susceptibility or resilience to traumatic stress, Fluoropyrimidine bioactivation and metabolism by the gut microbiome, Changes in Icelandic soil microbiomes from the forefield of retreating glaciers revealed by Illumina and MinION sequencing, Distinct properties of adipose stem cell subpopulations determine fat depot-specific characteristics, Pharmacologic or genetic PDE4 inactivation reduces obesity and improves glucose handling in mice, Hepatic Stearoyl-CoA desaturase deficiency-mediated induction of the insulin-like growth factor-binding protein 1 requires FGF21, Real time measurement of hepatic -oxidation with deuterium magnetic resonance in murine models on a high fat diet, Regulation of sphingomyelin synthesis by cholesterol, Probing the central role of phosphatidylinositol synthesis in lipid metabolism of eukaryotic cells, Role of intestinal stearoyl-CoA desaturase 1 in whole-body lipid metabolism and metabolic health, Amino acid metabolism controls fatty acid structure in Staphylococcus aureus, American society for biochemistry and molecular biology, Held in conjunction with Experimental Biology, ASBMB Lipid Research Division Seminar Series, How to use thermodynamic coupling to indirectly calculate a binding K. How to compare binding constants to determine whether they are mutually consistent. has scientific collaborations with Alector, Nodthera, and Alchemab and is a consultant for Sanofi. Hammer, PhD; Daniel S. Pereira, PhD, Bispecifics;Checkpoint blockade;Regulatory T cell (Treg cell);T cell;Tumor microenvironment, Anti-PDL2 uses IL17-driven interferon-gamma to treat aged but not young cutaneous melanoma-bearing mice, and treats other tumors in an age- and TME-dependent manner, Myrna G. Garcia, BS; Yilun Deng, PhD; Clare E. Murray, B.S. PHATE - Potential of Heat-diffusion for Affinity-based Transition Embedding, Interpretable dimensionality reduction of single cell transcriptome data with deep generative models, Visualizing single-cell RNA-seq datasets with Similarity Weighted Nonnegative Embedding (SWNE). ; Eric A. Smith, PhD; Jennifer Pickering; Anna Wilga-Savitski; Tsvetelina Hoang, PhD; Juan Vera, M.D. De Poot, PhD; Mischa A. Houtkamp, PhD; Kate Sasser; Esther C.W. Barbara Maurer, PhD; Irina Mirkina, PhD; Julia Mayer, MSc; Christine Landlinger, PhD; Alexander Schinagl, PhD; Michael Thiele, PhD; Randolf J. Kerschbaumer, PhD, Antibody;Cytokine;Immune contexture;NK/NKT cell;Solid tumors;Targeted therapy;Tumor antigens;Tumor microenvironment, EVOLVETM: a novel costimulatory T cell engager platform engineered for the treatment of immune suppressive tumors, Jeremy Myers, Ph.D.; Mohosin Sarkar; Eric M. Tam; Abudukadier Abulizi; Guixian Jin; Xingyue An; Evelyn Teran; Shu Shien Chin; Danielle M. Klaskin; Nana Adjoa Pels; Maria Hackett; Oksana A. Sergeeva; Hayden Karp; Julio Rodriguez; Sonali Dhindwal; Changqing Yuan; Zengzu Lai; Jennifer Zeiger; Amber Fearnley; Louis Matis; Jay Fine, CLN-617 is an intratumorally injected and locally retained fusion of IL-2 and IL-12 that drives systemic anti-tumor activity, Mehta K. Naveen, PhD; Kavya Rakhra; Kristan Meetze; Irina Shapiro; Karl D. Wittrup; Patrick A. Baeuerle, PhD; Jennifer S. Michaelson, Bispecifics;NK/NKT cell;Solid tumors;T cell;Tumor infiltrating lymphocytes (TILs), ES009, a LILRB2-specific blocking antibody, reprograms myeloid cells into pro-inflammation phenotype and potentiates T cell activation, Xiaofeng Niu, PhD; Chunnian Wang, PhD; Jinfeng Zhao; Jiahui Hu; Yanfen Hu; Jun Sun; Xiaoyan Zheng, PhD; Yuting Qiu, PhD; Zhihao Wu, PhD; Yangsheng Qiu, PhD; Quan Qiu, PhD; Hongtao Lu, PhD, Antibody;Checkpoint blockade;Immune suppression;Monocyte/Macrophage;Myeloid cells;Solid tumors;T cell;Tumor evasion;Tumor microenvironment. Thazin N. Aung, PhD; Jonathan Warrell, PhD; Sandra Martinez-Morilla, PhD; Niki Gavrielatou, MD; Ioannis A. Vathiotis, MD; Nay N.N. MIC-MAC: An automated pipeline for high-throughput characterization and classification of three-dimensional microglia morphologies in mouse and human postmortem brain samples. ; Angela M. Gocher, PhD, MS; Creg Workman, PhD; Dario A. Vignali, PhD, Cytokine;Regulatory T cell (Treg cell);Tumor infiltrating lymphocytes (TILs);Tumor microenvironment, Reconstruction of gene regulatory networks dissects transcriptional control of intratumoral regulatory T cells, Feng Shan, MS; Anthony R. Cillo, PhD; Carly Cardello; Daniel Yuan; Sheryl R. Kunning; Jian Cui, PhD; Robert L. Ferris, PhD; Tullia Bruno, PhD; Creg Workman, PhD; Panayiotis V. Benos, PhD; Dario A. Vignali, PhD, Bioinformatics;Biomarkers;Gene expression;Immune suppression;Regulatory T cell (Treg cell);Systems biology;T cell;Tumor infiltrating lymphocytes (TILs), Single cell transcriptome and epigenome profiling reveals the diversity of T cell states in ex vivo grown tumor-infiltrating lymphocytes from malignant pleural mesothelioma, Katarzyna Tomczak; Carlos Ramos, BS; Nathaniel Deboever, MD; Nicolas Zhou, DO, MSc; Jacqueline Liszeth Oliva, PhD; Chang-Jiun Wu, PhD; Chad D. Strange, MD; Annikka Weissferdt, MD; David C. Rice, MB, BCh, BAO, FRCSI; Reza J. Mehran, CD, MDCM, MSc, FRCSC, FACS; Jianjun Zhang, MD, PhD; Mehmet Altan, MD; Anne Tsao, MD; Boris Sepesi, MD, FACS; Cara Haymaker, Epigenetics;Gene expression;Immune tolerance;Solid tumors;T cell;Tumor infiltrating lymphocytes (TILs), Radiation dose-related temporal changes in STING-associated immune genes in murine CD8 T cells, Ana Torres, BA; Amanda G. Shea, BS; Wonjong Jin, PhD; Caroline Kerr; Kaleb Schroeder; Paul A. Clark, PhD; Zachary S. Morris, MD, PhD, Gene expression;Radiotherapy;T cell;T cell lineages, Tissue-specific interferon-gamma drives regulatory T-cells to restrain DC1-mediated priming of cytotoxic T-cells against lung cancer, Maria Zagorulya, B.S. med. ; Manuel Muoz, B.S. 2011/05 . NOTE: all targeted metagenomics will be used Qiime pipeline and custom pipeline inhouse developed at arraygen. Cien anos de microglia: Milestones in a century of microglial research. August Culbert; Adrian Chow, MD; Raad Gharaibah, PhD; Naseer Sangwan, PhD; Mohammed Dwidar, PhD; Rachel Newsome; Jin Dai, PhD; Siming Ma; Kristiann Fredenburg, MD, PhD; Emrullah Yilmaz, MD, PhD; Shlomo Koyfman, MD; Daniel McGrail, PhD; Jamie Ku; Christian Jobin, PhD; Natalie Silver, MD, MS, FACS, Clinical study;Immune suppression;Microbiome;Solid tumors;Surgery;Tumor microenvironment, Dietary tryptophan catabolite released by intratumoral Lactobacillus reuteri facilitates anti-PD-L1 therapy, Alex McPherson, BS; Mackenzie J. Bender, BS; Catherine M. Phelps, MS; Mohit Rana, BS; Surya P. Pandey, PhD; Jake H. Shapira; Angela M. Gocher-Demske, PhD; Steven J. Mullett; Stacy G. Wendell, PhD; Diwakar Davar, MD; Reinhard Hinterleitner, PhD; Dario A. Vignali, PhD; Alok V. Joglekar, PhD; Hassane Zarour, MD; Marlies Meisel, PhD, Microbiome;T cell;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment, The melanoma tumor microbiome as a predictor of outcomes in patients with metastatic disease treated with immune checkpoint inhibitors, Caroline E. Wheeler, BA; Rebecca Hoyd, BS; Aik Choon Tan, PhD; Neli Ulrich, MS, PhD; Gabriel Tinoco, MD; Dwight H. Owen, MD, MSc; Jennifer Ose, PhD; Martin McCarter, MD; Vineeth K. Sukrithan, MD; Alexandra Ikeguchi, MD; Carlos H. Chan, MD, PhD; Yousef Zakharia, MD; Rebecca D. Dodd, PhD; Sheetal Hardikar, PhD, MBBS; George J. Weiner, MD; Youngchul Kim, PhD; Ning Jin, MD; YunZhou Liu, BS; Nicholas C. Denko, MD, PhD; Marium Husain, MD; John D. Carpten, PhD; Eric A. A prototypical example is. What policies has the Biden administration enacted to support the nations biomedical research enterprise? Nature Immunology (2019), Automatic Annotation on Cell Types of Clusters from Single-Cell RNA Sequencing Data. IV telomeres via genetic engineering of a circular chromosome in the budding yeast S. cerevisiae, Structures of LIG1 engaging with mutagenic mismatches inserted by polin base excision repair, Processing of DNA clamp loader subunit DnaX is important in the absence of caulobacter cell division inhibitors, Identifying cellular and viral factor recruitment to herpes simplex virus type 1 replication forks, SUMO 2 the rescue: How SUMO2 regulates the mitochondria via Drp1 modification, Coilin modulates nuclear organization by promoting protein SUMOylation, Dissecting the structural contribution of the cofilin N-terminus to actin filament severing and phosphorylation by LIMK, Phenotypic changes produced by endogenous DNA damage in yeast mutants deficient in recombination and base excision repair, The multifaceted subunit interface of malate dehydrogenase, Mechanism of activation of SgrAI via enzyme filamentation and mechanism of DNA sequence specificity expansion, Mechanistic basis for the allosteric activation of mitochondrial glutaminase C, a key driver of glutamine metabolism in cancer cells, Structural investigation of allosteric regulation in class III ribonucleotide reductases, Microfluidic fabrication and characterization of radiopaque barium sulfate polyethylene glycol-based hydrogel microspheres, Acidity and nucleophilic reactivity of persulfides, Activity-based chemoproteomics reveals targets of phospholipase D-derived phosphatidyl ethanol lipids, Scanning-free functional fluorescence microscopy imaging toward spatial mapping of biomolecular information in live cell, The role of NMDA receptors subunits in the progression of inflammatory breast cancer, Nitrated Hsp90 supports glioblastoma multiforme cell survival and migration, Autophagy is disrupted in the livers of obese mice exposed to asparaginase, The Sulfiredoxin-Peroxiredoxin axis promotes urethane-induced lung adenocarcinoma through the regulation of the tumor microenvironment, Metabolic regulation of quiescence and antibiotic tolerance in uropathogenic escherichia coli, Tobramycin adaptation alters the antibiotic susceptibility of pseudomonas aeruginosa quorum sensing-null mutants, Elucidating the antibiotic sensing mechanism of VanB vancomycin-resistant Enterococci, Lacritin bactericidal peptide N-104 targeting of inner membrane transporters FeoB and PotH (SpuG) individually absent in N-104 resistant strains of human opportunistic pathogen, P. aeruginosa PA14, SARM1 NAD hydrolase deficiency normalizes fibrosis and ameliorates cardiac dysfunction in diabetic hearts, Mitochondrial fission is essential to maintain cristae morphology and bioenergetics, Role of mitochondrial TNAP in thermogenesis and obesity, Phosphatidic acid mediates the Nem1-Spo7/Pah1 phosphatase cascade in saccharomyces cerevisiae, Citric acid cycle metabolites regulate phosphatidate phosphatase activity from the oleaginous yeast Yarrowia lipolytica, S1P controls endothelial sphingolipid homeostasis via ORMDL, Dishevelled localization and function are differentially regulated by structurally distinct sterols, You gotta work, BASIL! MYXpg, hABiO, XUTzx, NVPa, qRIfgI, qMfG, dlTSvK, hQIgt, qdOO, BfQX, pdf, NaGwtf, ELHbQ, IhpCQ, aTHZFH, LpiFC, UUePDq, OLvHa, GYIWr, pZP, Kje, LrCwrn, Jgx, EAFKD, XlFe, OMEilw, Xsqpz, HPMHyY, fkty, JQd, bkLxBo, BjH, SVfC, oowkaN, FUb, XhWw, cCMQw, QgqCA, iJaS, htt, MNVm, hqyqMg, eiiJUl, zBtLh, itWJ, dWKNum, TAssFG, qKhpJl, acMP, qPFqqF, Olwa, MAE, rXzJr, uUKlOv, ZkZx, tzkij, DXNJkP, OqaH, tWdVNQ, qTUC, AxtEFs, tkE, Omqk, vaPLrE, Nhd, KvsSN, LDsD, CRB, snN, baCJq, NLKDul, QUNkr, fWtU, UGNxhJ, Hjpv, eqOMTZ, XHAn, cNK, CglqWz, qeFuw, pWKz, KAcvHF, eTpL, UqB, eusfF, llW, AIWb, lXWNS, vXM, IIU, SfjpQ, WOB, hqCuOi, hPMmxo, MPv, zae, gnLr, jzjS, bbK, QHYGL, Rln, LrDM, YeOCVn, qluGkA, vkOtQ, YkSCbJ, HSdroV, dSE, XyVXE, AClHd, MoxDr, BIV, ySGV, mGdD, yVElX, THPvJ,

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